GMB-475

GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.

Product parameters
Product item	GMB-475
CAS number	2490599-18-1
Molecular weight	861.93
Molecular formula	C43H46F3N7O7S
Specification	5mg，10mg，25mg，100mg，500mg，1g,10g
Traits	Light yellow to yellow powder
Design file	HNMR/HPLC/COA
Storage conditions	store at low temperture,keep away from direct sunlight　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 2 years
Delivery	3-5 days
Solubility	DMSO: 95 mg/mL (110.22 mM), Need ultrasonic ( < 1 mg/mL refers to the product slightly soluble or insoluble )
References	Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation - PubMed (nih.gov)
Shipment	By sea, By air, By express

公司信息.jpg

Hubei Chuchang Biotech Co.,Ltd. (CC-BIOTECH) is a scientific and technological enterprise which integrates R&D, production and sales. The company has established long-term cooperation with well-known pharmaceutical and chemical enterprises, scientific research institutions and university laboratories at home and abroad, and is committed to chemical customization synthesis, high value-added pharmaceutical intermediates and research and development of new drugs. It can provide customized production of products ranging from gram-scale for laboratory research, kilogram-scale to industrial ton-scale. At the same time, our company serves research institutes and colleges, provides active compounds and chemical reagents for scientific research, and accepts chemical custom synthesis.

Hubei Chuchang Biotech Co.,Ltd. covers pharmaceutical intermediates, API active compounds, polypeptide products, natural product molecules, high purity natural plant monomers,uv absorber,cosmetic product, scientific research reagents, biochemical reagents, chemical standard products, etc. At the same time, the company also accepts high purity compounds and monomers ordering business.

Since its establishment, the company has always adhered to the business concept of customer first and made continuous progress, which has won the high praise and trust of customers at home and abroad, such as universities, scientific research institutions and pharmaceutical and chemical enterprises, and established long-term and stable business relations with them. The company will continue to provide customers with better products and services with strict quality management system and stable product quality.