MRTX1133

MRTX1133 is a powerful, selective and non -covalent KRAS G12D inhibitor, showing that the KD KD of KRAS G12D is 0.2 PM. MRTX1133 can prevent the formation of SOS1 catalytic nucleotide exchange and/or KRAS G12D/GTP/RAF1 complexes, thereby inhibiting the mutant KRAS dependent signal transfer. MRTX1133 KRAS G12D mutant tumor cells have selective inhibitory and do not suppress KRAS wild cells. MRTX1133 has Nonol -level activity in cell experiments, and shows significant in vivo effects in the tumor model containing KRAS G12D mutations.

Product parameters
Product item	MRTX1133
CAS number	2621928-55-8
Molecular weight	600.63
Molecular formula	C33H31F3N6O2
Specification	5mg，10mg，25mg，100mg，500mg，1g,10g
Traits	Yellow to brown powder
Design file	HNMR/HPLC/COA
Storage conditions	Powder: -20°C for 3 years \| In solvent: -80°C for 2 years
Delivery	3-5 days
Solubility	DMSO: 230 mg/ml (382.93 mM), Need ultrasonic ( < 1 mg/mL refers to the product slightly soluble or insoluble )
References	Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor - PubMed (nih.gov)
Shipment	By sea, By air, By express

公司信息.jpg

Hubei Chuchang Biotech Co.,Ltd. (CC-BIOTECH) is a scientific and technological enterprise which integrates R&D, production and sales. The company has established long-term cooperation with well-known pharmaceutical and chemical enterprises, scientific research institutions and university laboratories at home and abroad, and is committed to chemical customization synthesis, high value-added pharmaceutical intermediates and research and development of new drugs. It can provide customized production of products ranging from gram-scale for laboratory research, kilogram-scale to industrial ton-scale. At the same time, our company serves research institutes and colleges, provides active compounds and chemical reagents for scientific research, and accepts chemical custom synthesis.

Hubei Chuchang Biotech Co.,Ltd. covers pharmaceutical intermediates, API active compounds, polypeptide products, natural product molecules, high purity natural plant monomers,uv absorber,cosmetic product, scientific research reagents, biochemical reagents, chemical standard products, etc. At the same time, the company also accepts high purity compounds and monomers ordering business.

Since its establishment, the company has always adhered to the business concept of customer first and made continuous progress, which has won the high praise and trust of customers at home and abroad, such as universities, scientific research institutions and pharmaceutical and chemical enterprises, and established long-term and stable business relations with them. The company will continue to provide customers with better products and services with strict quality management system and stable product quality.